MicroRNA Expression Patterns Related to Merkel Cell Polyomavirus Infection in Human Merkel Cell Carcinoma
نویسندگان
چکیده
منابع مشابه
MicroRNA Expression Patterns Related to Merkel Cell Polyomavirus Infection in Human Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is an aggressive and lethal type of neuroendocrine skin cancer. Mutated Merkel cell polyomavirus (MCV) is commonly found in MCC, and leads to upregulation of the survivin oncogene. However, ∼20% of MCC tumors do not have detectable MCV, suggesting alternative etiologies for this tumor type. In this study, our aim was to evaluate microRNA (miRNA) expression profiles a...
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conclusions the findings of this study are consistent with the hypothesis that local, systemic, or tumor-induced immunosuppression may allow the mcpyv to initiate skin aggressive cancer. it is necessary to maintain regular check over patients taking immunosuppressive medications for mcpyv infection. since there is not any information about detection and molecular biology analysis of mcpyv among...
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We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.
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Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62%) of healthy controls. MCPyV thus appears to be widespread.
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The RNA viruses hepatitis C virus and human T-cell lymphotropic virus type I (or human T-cell leukaemia virus type 1), and the DNA viruses hepatitis B virus, high-risk human papillomaviruses, human herpes virus-8 (Kaposi’s sarcoma-associated herpes virus) and Epstein Barr virus are acknowledged as carcinogenic to humans. Human polyomaviruses have oncogenic potentials in cell cultures and animal...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2014
ISSN: 0022-202X
DOI: 10.1038/jid.2013.355